Metabolic
Eloralintide
Also known as LY3841136
Investigational; phase 3 trials starting
In simple words: An experimental weekly injection that copies amylin, a hormone that helps you feel full.
How it works
Amylin is released with insulin after meals; activating its receptors slows stomach emptying and lowers appetite through a different pathway from GLP-1.
Targets: Amylin receptors · Class: Amylin receptor agonist
Uses, latest studies & pairings
Typically used for
- Obesity and overweight (investigational).
- Lilly sees it as a possible option on its own or alongside other weight medicines for people who need more weight loss.
Commonly paired with
- Strength training and enough protein (about 1.2–1.6 g per kg of body weight a day, unless your doctor says otherwise) to protect muscle while losing weight.
- As an amylin medicine, it isn't expected to carry the GLP-1 thyroid warning, but its long-term safety is still unknown.
Latest studies & news
- Nov 2025
Phase 2 (263 adults, 48 weeks, published in The Lancet): up to 20.1% average weight loss on the top dose versus 0.4% on placebo. Nausea (up to 64%) and tiredness were the most common side effects, and were lower with a slower step-up.
Source: Healio: amylin agonist eloralintide induces meaningful weight loss (2025) - Next
Lilly planned to start phase 3 trials at the end of 2025. Not approved.
What the research shows
Human clinical evidence
Human- Phase 2 (2025, The Lancet, 263 adults, 48 weeks): average weight loss up to 20.1% on the top dose versus 0.4% on placebo. Phase 3 trials are starting.
Animal and lab results suggest what might happen; they don't prove an effect in people.
Safety & what to watch
- Nausea (up to 64% on some doses) and tiredness were the most common side effects in phase 2, and were lower with a slower step-up.
- Investigational; not approved.
Amounts
No dose is given for unapproved substances. If you are considering it, discuss it with a licensed clinician who knows your history and bloodwork.
📦 My peptide supply kit
The supplies I use, in one Amazon list. Only use them for medicines your clinician prescribes. Never share or reuse needles, and put used ones in a sharps container.
Studies & references
Draft profile pending editorial review. Educational only, not medical advice. Never start, stop or change a medicine without your prescriber.