Inflammation research
KPV
Also known as Lys-Pro-Val
Not an approved medicine; preclinical research
In simple words: A three-amino-acid fragment of a natural anti-inflammatory hormone (alpha-MSH).
How it works
In lab studies it dampens inflammatory signaling (NF-κB) inside cells, including gut-lining cells.
Targets: Inflammatory signalling (reported) · Class: Tripeptide; C-terminal fragment of α-MSH
Uses, latest studies & pairings
Typically used for
- Marketed for gut inflammation (colitis), skin inflammation and wound healing.
- Evidence is from mice and cells only.
Commonly paired with
- BPC-157 for the gut, and the KLOW blend (GHK-Cu, BPC-157, TB-500 and KPV). No combination has been studied in people.
Latest studies & news
- Jul 2026
An FDA advisory committee voted to recommend letting pharmacies compound KPV. Reports differ on the exact vote and use. This is not binding; the FDA hasn't made a final decision.
Source: Mintz: what the FDA advisory committee peptide votes do and don't mean (July 2026)
What the research shows
Human clinical evidence
Human- No human clinical trials have been published.
Animal research
Animal- In mouse models of colitis it reduced gut inflammation.
Laboratory / in-vitro
In-vitro- Cell studies show reduced inflammatory signaling.
Animal and lab results suggest what might happen; they don't prove an effect in people.
Safety & what to watch
- Human safety is unknown. Not approved; research-only products are unregulated.
Amounts
No dose is given for unapproved substances. If you are considering it, discuss it with a licensed clinician who knows your history and bloodwork.
📦 My peptide supply kit
The supplies I use, in one Amazon list. Only use them for medicines your clinician prescribes. Never share or reuse needles, and put used ones in a sharps container.
Studies & references
Draft profile pending editorial review. Educational only, not medical advice. Never start, stop or change a medicine without your prescriber.