Metabolic
Survodutide
Also known as BI 456906
Investigational; in Phase 3 development
In simple words: An experimental weekly injection that acts on both the GLP-1 and glucagon receptors.
How it works
GLP-1 lowers appetite; glucagon raises energy use and pushes the liver to burn stored fat, which is why it is being studied for fatty liver disease.
Targets: Glucagon receptor, GLP-1 receptor · Class: Dual glucagon / GLP-1 receptor agonist
Uses, latest studies & pairings
Typically used for
- Obesity and overweight.
- Fatty liver disease (MASLD and MASH with scarring), where its glucagon action on the liver may give it an edge.
Commonly paired with
- Strength training and enough protein (about 1.2–1.6 g per kg of body weight a day, unless your doctor says otherwise) to protect muscle while losing weight.
- Not combined with other GLP-1 medicines: they work on the same receptors, so stacking adds side effects, not safety.
Latest studies & news
- Jun 2026
SYNCHRONIZE-1 (725 adults, 76 weeks): up to 16.6% average weight loss versus 3.2% on placebo. In a substudy, visceral (deep belly) fat fell by up to 34% and liver fat by up to 63%. Side effects were mostly stomach-related.
Source: PharmaTimes: survodutide delivers 16.6% weight loss in phase 3 (2026) - Jun 2026
SYNCHRONIZE-MASLD (218 people, 48 weeks) also met its main goals, published in Nature Medicine.
- 2024
Phase 2 MASH trial: up to 83% of people had their MASH improve, versus 18% on placebo.
- Next
LIVERAGE trials in MASH with scarring are due to report. Not yet filed for approval.
What the research shows
Human clinical evidence
Human- Phase 2 trials reported meaningful weight loss and improvements in liver fat and MASH.
- Phase 3 SYNCHRONIZE-1 (2026, 76 weeks): up to 16.6% average weight loss versus 3.2% on placebo, with large cuts in liver and visceral fat.
Animal and lab results suggest what might happen; they don't prove an effect in people.
Safety & what to watch
- Gastrointestinal side effects were the most common in trials.
- Not approved; investigational only.
Amounts
No dose is given for unapproved substances. If you are considering it, discuss it with a licensed clinician who knows your history and bloodwork.
📦 My peptide supply kit
The supplies I use, in one Amazon list. Only use them for medicines your clinician prescribes. Never share or reuse needles, and put used ones in a sharps container.
Studies & references
Draft profile pending editorial review. Educational only, not medical advice. Never start, stop or change a medicine without your prescriber.